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  • Nutritional Science

  • Epidemiology 
  • Human Physiolog
  • General Biology
  • Molecular Biology
  • Microbiology


2019 PhD in Neuropharmacology, The Hong Kong Polytechnic University
2006 MA in Chinese Studies, The Hong Kong University of Science and Technology
2004 BSc (Hons) in Biochemistry, The Hong Kong University of Science and Technology


2021 - Present Teaching Fellow, Faculty of Science and Technology, the Technological and Higher Education Institute of Hong Kong
2020 - 2021 Project Manager, ZhaoKe (HK) Ophthalmology Pharmaceutical
2019 - 2020 Research Associate, Division of Life Science, The Hong Kong University of Science and Technology
2014 - 2015 Research Assistant, Applied Biology & Chemical Technology, The Hong Kong Polytechnic University
2013 - 2014 Research Assistant, Division of Life Science, The Hong Kong University of Science and Technology
2013 - 2013 Research Assistant, Department of Pharmacy, The Chinese University of Hong Kong
2007 - 2013

Research Assistant, Applied Biology & Chemical Technology, The Hong Kong Polytechnic University

2006 - 2007 Research Assistant, Department of Biochemistry, The Hong Kong University of Science and Technology


  •  Molecular and Cellular mechanisms of Neurodegenerative Disorders 
  •  Development of novel treatment for Alzheimer’s disease and Parkinson’s disease


  • Xia Y, Wu Q, Mak SH, Liu EYL, Zheng BZY, Dong TTX, Pi R, Tsim KWK. (2022) Regulation of acetylcholinesterase during the lipopolysaccharide-induced inflammatory responses in microglial cells. FASEB J. 36(3):e22189.
  • Chen C*, Lu J*, Peng W*, Mak SH*, Yang Y, Zhu Z, Wang S, Hou J, Zhou X, Xin W, Hu Y, Tsim KWK, Han Y, Liu Q, Pi RB. (2021)  Acrolein, an endogenous aldehyde induces Alzheimer's disease-like pathologies in mice: A new sporadic AD animal model. Pharmacol Res. 175:106003. *The authors contributed equally to this work.
  • Gao X, Xia TC, Mak SH, Kwan KL, Zheng ZY, Xiao J, Dong TT, Tsim KWK. (2021) Luteolin stimulates the NGF-induced neurite outgrowth in cultured PC12 cells through binding with NGF and potentiating its receptor signalling. Food Funct. 12(22):11515-11525.
  • Liu EYL, Mak SH, Kong X, Xia Y, Kwan KKL, Xu ML, Tsim KWK. (2021) Tacrine Induces Endoplasmic Reticulum-Stressed Apoptosis via Disrupting the Proper Assembly of Oligomeric Acetylcholinesterase in Cultured Neuronal Cells. Mol Pharmacol.;100(5):456-469.
  • Mak SH, Li WM, Fu HJ, Luo JL, Cui W, Hu SQ, Tsim, KWK, Pi RB, Han YF (2021) Promising dimeric AChE inhibitors for neurodegenerative disorders: from relieving symptoms to modifying diseases through multi-target. Journal of Neurochemistry. 158(6):1381-1393.
  • Hu WH*, Mak SH*, Zheng ZY, Xia YJ, Xu ML, Duan R, Dong TT, Li SP, Zhan CS, Shang XH, Tsim KW. (2020) Shexiang Baoxin Pill, a Traditional Chinese Herbal Formula, Rescues the Cognitive Impairments in APP/PS1 Transgenic Mice. Front Pharmacol.11:1045. *The authors contributed equally to this work.
  • Mak SH, Liu Z, Wu L, Guo B, Luo F, Liu Z, Hu S, Wang J, Cui G, Sun Y, Wang Y, Zhang G, Han Y, Zhang Z. (2020) Pharmacological Characterizations of anti-Dementia Memantine Nitrate via Neuroprotection and Vasodilation in Vitro and in Vivo. ACS Chem Neurosci. 11(3):314-327.
  • Zhang L*, Chen C*, Mak SH*, Lu J, Wu Z, Chen Q, Han Y, Li Y, Pi R. (2019) Advance of sporadic Alzheimer's disease animal models. Med Res Rev. 40(1):431-458. *The authors contributed equally to this work.
  • Hu SQ*, Mak SH*, Zuo X, Li H, Wang Y, Han Y. (2018) Neuroprotection Against MPP+-Induced Cytotoxicity Through the Activation of PI3-K/Akt/GSK3β/MEF2D Signaling Pathway by Rhynchophylline, the Major Tetracyclic Oxindole Alkaloid Isolated From Uncaria rhynchophylla. Front Pharmacol. 9:768. *These authors have contributed equally to this work
  • Lin JJ*, Mak SH*, Zhang JC, Wang JL, Xu DL, Hu SQ, Zhang ZJ, Wang QW W, Han YF, Cui W. (2017) Assessment of Neuronal Viability Using Fluorescein Diacetate-Propidium Iodide Double Staining in Cerebellar Granule Neuron Culture. J Vis Exp. (123). *These authors have contributed equally to this work.
  • Xu DP, Chen HY, Mak SH, Hu SQ, Tsim KW, Hu YJ, Sun Y, Zhang G, Wang YQ, Zhang ZJ, Han YF. (2016) Neuroprotection against glutamate-induced excitotoxicity and induction of neurite outgrowth by T-006, a novel multifunctional derivative of tetramethylpyrazine in neuronal cell models. Neurochem Int. 99:194-205.
  • Hu SQ, Cui W, Mak SH, Xu DP, Hu YJ, Tang J, Choi C, Lee MY, Pang Y, Han YF. (2015) Substantial Neuroprotective and Neurite Outgrowth-Promoting Activities by Bis(propyl)-cognitin via the Activation of Alpha7-nAChR, a Promising Anti-Alzheimer's Dimer. ACS Chem Neurosci. 6(9):1536-45.
  • Mak SH, Luk WW, Cui W, Hu S, Tsim KW, Han YF. (2014) Synergistic Inhibition on Acetylcholinesterase by the Combination of Berberine and Palmatine Originally Isolated from Chinese Medicinal Herbs. J Mol Neurosci. 53(3):511-6.
  • Hu SQ, Cui W, Mak SH, Tang J, Choi C, Pang Y, Han YF. (2013) Bis(propyl)-cognitin protects against glutamate-induced neuro-excitotoxicity via concurrent regulation of NO, MAPK/ERK and PI3-K/Akt/GSK3β pathways. Neurochem Int. 62(4):468-77.
  • Cui W, Zhang Z, Li W, Hu S, Mak SH, Zhang H, Han R, Yuan S, Li S, Sa F, Xu D, Lin Z, Zuo Z, Rong J, Ma ED, Choi TC, Lee SM, Han Y. (2012) Unexpected protection against MPP(+) -induced neurotoxicity via selectively and directly inhibiting neuronal NOS by anti-cancer agent SU4312. Br J Pharmacol. 168(5):1201-14.
  • Hu S, Han R, Mak SH, Han YF. (2011) Protection against 1-methyl-4-phenylpyridinium ion (MPP+)-induced apoptosis by water extract of ginseng (Panax ginseng C.A. Meyer) in SH-SY5Y cells. J Ethnopharmacol. 26;135(1):34-42.
  • Li W, Mak SH, Jiang H, Wang Q, Pang Y, Chen K, Han YF. (2009) Novel anti-Alzheimer's dimer Bis(7)-cognitin: cellular and molecular mechanisms of neuroprotection through multiple targets. Neurotherapeutics. 6(1):187-201.